Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering

Aydogdu M. O., Chou J., Altun E., EKREN N., Cakmak S., Eroglu M., ...Daha Fazla

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.68, sa.5, ss.243-255, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 5
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/00914037.2018.1443930
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.243-255
  • Anahtar Kelimeler: Cardiovascular tissue engineering, collagen, electrospinning, ethyl cellulose, polycaprolactone, SCAFFOLD, PROLIFERATION, FABRICATION, NANOFIBERS, HEPARIN, PATIENT, GRAFTS
  • Marmara Üniversitesi Adresli: Evet

Özet

A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability.