Omics-Driven Biomarkers of Psoriasis: Recent Insights, Current Challenges, and Future Prospects

Aydin B., ARĞA K. Y., KARADAĞ A. S.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, cilt.13, ss.611-625, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2147/ccid.s227896
  • Dergi Adı: CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.611-625
  • Anahtar Kelimeler: psoriasis, biomarker, omics, inflammatory skin diseases, personalized medicine, psoriasis biomarkers, omics biomarkers, ELEVATED SERUM-LEVELS, LONG NONCODING RNAS, DISEASE SEVERITY, CELL ACTIVATION, SKIN REVEALS, TNF-ALPHA, EXPRESSION, METHYLATION, GENE, KERATINOCYTES
  • Marmara Üniversitesi Adresli: Evet

Özet

Advances in omics technologies have made it possible to unravel biomarkers from different biological levels. Intensive studies have been carried out to uncover the dysregulations in psoriasis and to identify molecular signatures associated with the pathogenesis of psoriasis. In this review, we presented an overview of the current status of the omics-driven biomarker research and emphasized the transcriptomic, epigenomic, proteomic, metabolomic, and glycomic signatures proposed as psoriasis biomarkers. Furthermore, insights on the limitations and future directions of the current biomarker discovery strategies were discussed, which will continue to comprehend broader visions of psoriasis research, diagnosis, and therapy especially in the context of personalized medicine.