In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

BAŞARAN, İSMET; SİNAN, SELMA; ÇAKIR, ÜMİT; Bulut, Mustafa; ARSLAN, OKTAY; Ozensoy, Ozen

doi:10.1080/14756360701404100

In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

Atıf İçin Kopyala

BAŞARAN İ., SİNAN S., ÇAKIR Ü., Bulut M., ARSLAN O., Ozensoy O.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.23, sa.1, ss.32-36, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 1
Basım Tarihi: 2008
Doi Numarası: 10.1080/14756360701404100
Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.32-36
Marmara Üniversitesi Adresli: Evet

Özet

A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, namely 6,7-dihydroxy-3-phenyl-2H-chromen-2-one (DPC), were synthesized. These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.