Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2025 – Winter Editio, 26 - 28 Kasım 2025, ss.77-78, (Özet Bildiri)
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, plays a vital role in maintaining the balance between excitatory and inhibitory neural signaling. Although traditionally considered incapable of crossing the blood–brain barrier (BBB), recent evidence suggests the existence of specific transporter systems that facilitate its passage. In parallel, advances in 3D bioprinting have enabled the development of functional biomaterial systems for drug delivery and tissue regeneration (1). In this study, polycaprolactone (PCL) and poly(vinyl alcohol) (PVA) composite scaffolds were fabricated using 3D printing technology to evaluate their potential as carriers for GABA in neuropharmacological and wound-healing applications(2). Four types of scaffolds—PCL, PCL-PVA, PCLPVA-GABA, and PCL-PVA-GABA-PCL—were prepared, with GABA incorporated at three different concentrations (15 mg, 30 mg, and 45 mg). The structural, chemical, and morphological characteristics of the scaffolds were analyzed using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Thermal, mechanical, and swelling properties were also investigated to assess scaffold performance and stability. The results demonstrated that GABA was successfully incorporated into the PCL/PVA matrix, forming a homogeneously distributed and stable composite structure. The fabricated scaffolds exhibited suitable mechanical integrity, thermal stability, and swelling behavior for potential biomedical applications. Overall, these findings indicate that GABA-loaded PCL/PVA scaffolds fabricated via 3D printing hold promise as biocompatible materials for controlled drug delivery and regenerative medicine application