Fucosphere - New microsphere carriers for peptide and protein delivery: Preparation and in vitro characterization

Sezer A. D., Akbuga J.

JOURNAL OF MICROENCAPSULATION, cilt.23, sa.5, ss.513-522, 2006 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/02652040600687563
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.513-522
  • Anahtar Kelimeler: fucoidan, chitosan, controlled release, protein, microsphere, TREATED ALGINATE BEADS, CONTROLLED-RELEASE, CHITOSAN MICROSPHERES, SUSTAINED-RELEASE, BROWN-ALGAE, MICROCAPSULES, DRUG, SYSTEMS
  • Marmara Üniversitesi Adresli: Hayır

Özet

Purpose: Fucoidan is a complex polysaccharide containing sugars and high amounts of sulphate derived from marine brown algaes. In this study, a new microsphere-delivery system based on cross-linking of fucoidan with chitosan, named Fucosphere, was evaluated as a drug carrier. Bovine serum albumin (BSA) was used as a model protein. The effect of fucoidan (1.5, 1.75, 2.0 and 2.5%), chitosan (0.25, 0.50 and 0.75%) and protein (0.25, 0.50 and 0.75%) concentrations, the origin of chitosan and the preparation methods of the particles on the microsphere characteristics were evaluated.