Effect of Apium graveolens extract on the surface morphology and characteristics of calcium pyrophosphate crystals

Polat S. , Sayan P.

Journal Of Crystal Growth, cilt.562, ss.126083, 2021 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 562
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jcrysgro.2021.126083
  • Dergi Adı: Journal Of Crystal Growth
  • Sayfa Sayıları: ss.126083


This aim of the present study was to investigate the crystallization and physical characteristics of the triclinic

calcium pyrophosphate dihydrate (t-CPPD) and monoclinic calcium pyrophosphate tetrahydrate β (m-CPPT β)

crystals created in pure media and in the presence of Apium graveolens extract. The structure, functional groups,

crystal morphology, and size of the crystals were investigated experimentally using X-ray diffraction, Fourier

transform infrared (FTIR) spectroscopy, scanning electron microscopy, atomic force microscopy, and a particle

size analyzer. The smaller crystals were created in the presence of the extract media and displayed changes in the

t-CPPD crystal shapes from rod like to rounded in addition to rod-like crystals. Zeta potential analyses showed

that adding A. graveolens extract resulted in a more negative crystal surface energy (􀀀 36.7 ± 1.1 mV) than that in

pure media, which was 􀀀 28.6 ± 1.3 mV. In addition, the thermal decomposition characteristics of the t-CPPD

and m-CPPT β crystals were simultaneously investigated using thermogravimetric analysis combined with FTIR

and the main evolved product was determined as H2O. The present study analyzed the structural, morphological,

and thermal properties of t-CPPD and m-CPPT β to provide more comprehensive information on how

A. graveolens extract helps prevent the formation of t-CPPD and m-CPPT β crystals. This information can be an

important step in long-term development of an effective therapeutic treatment.