NLRP1-Mediated Antidepressant Effect of Ketamine in Chronic Unpredictable Mild Stress Model in Rats

Aricioglu F., Yalcinkaya C., Ozkartal C. S., Tuzun E., ŞİRVANCI S., Kucukali C. I., ...Daha Fazla

PSYCHIATRY INVESTIGATION, cilt.17, sa.4, ss.283-291, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30773/pi.2019.0189
  • Dergi Adı: PSYCHIATRY INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE
  • Sayfa Sayıları: ss.283-291
  • Anahtar Kelimeler: Depression, Ketamine, Inflammasome, NLRP1, Glia, NF-KAPPA-B, NITRIC-OXIDE SYNTHASE, NEURONAL NLRP1 INFLAMMASOME, MAJOR DEPRESSIVE DISORDER, ANIMAL-MODEL, EXPRESSION, NEUROINFLAMMATION, ACTIVATION, MECHANISMS, NEUROBIOLOGY
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective NOD-like receptor protein 1 (NLRP1) inflammasome complex has been recently associated with chronic unpredictable mild stress (CUMS) model of depression. Our aim was to investigate whether ketamine-induced antidepressant effect is associated with suppression of NLRP1.