Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening

Creative Commons License

Akkelle B., Volkan B., Tutar E., Ertem D.

Indian Pediatrics, cilt.59, sa.11, ss.867-870, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s13312-022-2645-8
  • Dergi Adı: Indian Pediatrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.867-870
  • Anahtar Kelimeler: Asymptomatic, Serology, Silent disease
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening. Methods: We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs (n=24) were compared with index celiacs (n=186). Results: At diagnosis, sibling celiacs were older than index celiacs (mean (SD) 10.4 (2.7) vs 8.2 (4.3) years; P=0.02). There were no significant differences between sibling and index celiacs in terms of serum anti-tTG IgA titer (≥10xULN, 83.3% vs 85%), and most of the patients had moderate/severe villous atrophy in both groups. The rates of iron deficiency anemia, folic acid deficiency, wasting and stunting were comparable between sibling and index celiac patients. Conclusions: Siblings with CD were older than index children with CD at diagnosis, and their characteristics were similar to symptomatic index children with CD, despite not having any complaints.