Quorum-sensing inhibitor potential of trans-anethole aganist Pseudomonas aeruginosa

AYDEMİR D., Cifci G., Aviyente V., Bosgelmez-Tinaz G.

JOURNAL OF APPLIED MICROBIOLOGY, vol.125, no.3, pp.731-739, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 125 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.1111/jam.13892
  • Journal Name: JOURNAL OF APPLIED MICROBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.731-739
  • Keywords: antibiotic resistance, P. aeruginosa, quorum-sensing inhibitors, trans-anethole, virulence factors, MOLECULAR DOCKING, BIOFILM FORMATION, PLANT, VIRULENCE, ANTIBIOTICS, ESTRAGOLE, BACTERIA, MOTILITY, EUGENOL, SYSTEM
  • Marmara University Affiliated: Yes

Abstract

AimsQuorum sensing (QS) is a cell-cell communication system used by a broad spectrum of pathogenic bacteria to control the expression of their virulence genes. The interruption of QS systems of pathogenic bacteria has been considered as a novel way to fight bacterial diseases. In this study, trans-anethole, the main component of anise (Pimpinella anisum) oil was examined for its QS inhibitor (QSI) potential in an attempt to identify novel QSI compound effective against opportunistic pathogen Pseudomonas aeruginosa.