Magnesium and anti-phosphate treatment with bisphosphonates for generalised arterial calcification of infancy: A case report

Dursun F., Öztürk T. A., GÜVEN S., Kırmızıbekmez H., Karabulut G. S., Kalın S., ...Daha Fazla

JCRPE Journal of Clinical Research in Pediatric Endocrinology, cilt.11, sa.3, ss.311-318, 2019 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4274/jcrpe.galenos.2018.2018.0204
  • Dergi Adı: JCRPE Journal of Clinical Research in Pediatric Endocrinology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.311-318
  • Anahtar Kelimeler: Etidronate, Etidronategeneralized arterial calcification, Generalized arterial calcification, Infant, Infant, Magnesium, Magnesium, Treatment, Treatment
  • Marmara Üniversitesi Adresli: Evet

Özet

Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries and resultant arterial stenosis. Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach. The case reported here was a patient with severe GACI diagnosed at three months of age who had no response to bisphosphonate treatment, but clinically improved after the initiation of magnesium and anti-phosphate (using calcium carbonate) treatments. In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.