Characterization of 3 oral squamous cell carcinoma cell lines with different invasion and/or metastatic Potentials

Erdem N. F., Carlson E. R., Gerard D. A., Ichiki A. T.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, cilt.65, sa.9, ss.1725-1733, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 9
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.joms.2006.11.034
  • Dergi Adı: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1725-1733
  • Marmara Üniversitesi Adresli: Hayır

Özet

Purpose: Proteolytic enzymes may confer specific types of invasion and metastasis in patients with oral squamous cell carcinoma (OSCC). The purpose of this study was to determine if OSCC that invades adjacent bone has different proteolytic enzyme expression profiles than OSCC that metastasizes to lymph nodes or distant organs. Three OSCC cell lines, BHY, HSC-3, and HN, with known behavior regarding bone invasion and lymph node and distant metastatic profiles, were evaluated. The characteristics of a control, human normal nasal epithelial cell line (HNEC), and BHY, HSC-3 and HN were evaluated with regard to their expression of the matrix metalloproteinases and cathepsins.