Synthesis and antituberculosis activity of new N-phenyl-N '-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas

Karakus S. , Rollas S.

FARMACO, cilt.57, sa.7, ss.577-581, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Konu: 7
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0014-827x(02)01252-1
  • Dergi Adı: FARMACO
  • Sayfa Sayıları: ss.577-581


In this study, eight original N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea, derivatives were synthesized and tested for antituberculosis activity. Antituberculosis activities of the synthesized compounds were screened in vitro using BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv at 6.25 mug/ml. The highest inhibition observed with the synthesized compounds is 67% for N-phenyl-N'-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.