Protein-Peptide Interactions Revolutionize Drug Development


Sarıyar Akbulut B. , Özkırımlı Ölmez E.

in: Binding Protein, Ktob Abdelmohsen, Editor, InTech, Rijeka, pp.49-72, 2012

  • Publication Type: Book Chapter / Chapter Vocational Book
  • Publication Date: 2012
  • Publisher: InTech
  • City: Rijeka
  • Page Numbers: pp.49-72
  • Editors: Ktob Abdelmohsen, Editor

Abstract

For many years, there existed bias against peptides as pharmaceutical agents. The

application of breathtaking advances in genetic engineering and recombinant technology to

protein studies has changed this general mindset. Although the delivery of the peptides to

the target sites is considered as an important challenge, recent technological advances in

formulation, delivery and chemistry are underway to overcome this limitation. Peptide drugs

are gaining increased interest from the pharmaceutical industry and a large number of

peptide-based drugs are now being marketed. In this review design and development of

peptide based drugs that bind and inhibit some important protein targets are discussed.