Is serum Klotho protective against atherosclerosis in patients with type 1 diabetes mellitus?

Keles N., Dogan B., Kalcik M., ÇALIŞKAN M., Keles N. N., Aksu F., ...Daha Fazla

JOURNAL OF DIABETES AND ITS COMPLICATIONS, cilt.30, sa.1, ss.126-132, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jdiacomp.2015.09.013
  • Dergi Adı: JOURNAL OF DIABETES AND ITS COMPLICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.126-132
  • Anahtar Kelimeler: Atherosclerosis, Epicardial fat thickness, Flow mediated dilation, Diabetes mellitus type 1, Klotho, PERIPHERAL VASCULAR-DISEASE, INTIMA-MEDIA THICKNESS, ENDOTHELIAL DYSFUNCTION, CLINICAL-APPLICATIONS, CORONARY-ARTERIES, BRACHIAL-ARTERY, EPICARDIAL FAT, ECHOCARDIOGRAPHY, STRAIN, TISSUE
  • Marmara Üniversitesi Adresli: Hayır

Özet

Objective: Klotho deficiency is associated with several metabolic disorders. Two dimensional (2D) longitudinal strain (IS) of left ventricle (LV), carotid artery intima-media thickness (CIMT), flow-mediated dilation (FMD) of brachial artery and epicardial fat thickness (EFT) have been reported to be early predictors of atherosclerosis. We aimed to investigate the relationship between serum Klotho levels and these early predictors of atherosclerosis in patients with type 1 diabetes mellitus (DM).