Is serum Klotho protective against atherosclerosis in patients with type 1 diabetes mellitus?

Keles N., Dogan B., Kalcik M., ÇALIŞKAN M., Keles N. N., Aksu F., ...More

JOURNAL OF DIABETES AND ITS COMPLICATIONS, vol.30, no.1, pp.126-132, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jdiacomp.2015.09.013
  • Journal Name: JOURNAL OF DIABETES AND ITS COMPLICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.126-132
  • Keywords: Atherosclerosis, Epicardial fat thickness, Flow mediated dilation, Diabetes mellitus type 1, Klotho, PERIPHERAL VASCULAR-DISEASE, INTIMA-MEDIA THICKNESS, ENDOTHELIAL DYSFUNCTION, CLINICAL-APPLICATIONS, CORONARY-ARTERIES, BRACHIAL-ARTERY, EPICARDIAL FAT, ECHOCARDIOGRAPHY, STRAIN, TISSUE
  • Marmara University Affiliated: No

Abstract

Objective: Klotho deficiency is associated with several metabolic disorders. Two dimensional (2D) longitudinal strain (IS) of left ventricle (LV), carotid artery intima-media thickness (CIMT), flow-mediated dilation (FMD) of brachial artery and epicardial fat thickness (EFT) have been reported to be early predictors of atherosclerosis. We aimed to investigate the relationship between serum Klotho levels and these early predictors of atherosclerosis in patients with type 1 diabetes mellitus (DM).