CYP 2D6*4 polymorphism in Polycythemia vera patients in Turkish population

Okat Z., Ciftci K. U., Yaman K., Toplayici S., Kurt E., Taga Y.

MARMARA MEDICAL JOURNAL, vol.31, no.2, pp.61-67, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5472/marumj.430790
  • Journal Name: MARMARA MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.61-67
  • Keywords: Cytochrome P450 2D6, Genetic polymorphism, Polycythemia vera (PV), ACUTE LYMPHOBLASTIC-LEUKEMIA, CYTOCHROME-P450 2D6, GENETIC POLYMORPHISMS, MYELOPROLIFERATIVE DISORDERS, DRUG-METABOLISM, LUNG-CANCER, SUSCEPTIBILITY, GSTM1, DEBRISOQUINE, GSTT1
  • Marmara University Affiliated: Yes

Abstract

Objective: Many studies have shown the association of susceptibility to several cancers with gene encoding enzymes' polymorphisms which engage in xenobiotics' biotransformation. In this study, the main purpose is to search the relation between cytochrome P450 (CYP) 2D6* 4 polymorphisms and Polycythemia vera (PV) incidence in Turkish population.