CYP 2D6*4 polymorphism in Polycythemia vera patients in Turkish population

Okat Z., Ciftci K. U., Yaman K., Toplayici S., Kurt E., Taga Y.

MARMARA MEDICAL JOURNAL, cilt.31, sa.2, ss.61-67, 2018 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5472/marumj.430790
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.61-67
  • Anahtar Kelimeler: Cytochrome P450 2D6, Genetic polymorphism, Polycythemia vera (PV), ACUTE LYMPHOBLASTIC-LEUKEMIA, CYTOCHROME-P450 2D6, GENETIC POLYMORPHISMS, MYELOPROLIFERATIVE DISORDERS, DRUG-METABOLISM, LUNG-CANCER, SUSCEPTIBILITY, GSTM1, DEBRISOQUINE, GSTT1
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Many studies have shown the association of susceptibility to several cancers with gene encoding enzymes' polymorphisms which engage in xenobiotics' biotransformation. In this study, the main purpose is to search the relation between cytochrome P450 (CYP) 2D6* 4 polymorphisms and Polycythemia vera (PV) incidence in Turkish population.