Avci T., Altan E., Aytar C., Kanli Z., Kaya E., Seyhan S. A., ...Daha Fazla
POLYMERS, cilt.18, sa.15, ss.1-26, 2026 (SCI-Expanded, Scopus)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
18
Sayı:
15
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Basım Tarihi:
2026
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Doi Numarası:
10.3390/polym18151857
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Dergi Adı:
POLYMERS
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Derginin Tarandığı İndeksler:
Academic Search Ultimate (EBSCO), Engineering Source (EBSCO), Scopus, Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest), Science Citation Index Expanded (SCI-EXPANDED), Chemical Abstracts Core, Compendex, INSPEC
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Sayfa Sayıları:
ss.1-26
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Marmara Üniversitesi Adresli:
Evet
Özet
Melanoma excision procedures frequently result in complex wounds that require simultaneous tumor suppression and tissue regeneration. However, current post-surgical care heavily relies on synthetic drugs, facing challenges like antibiotic resistance and delayed healing. To address this notable gap, this study introduces a novel “mineral-botanical” hybrid nanofibrous dressing to reduce reliance on conventional synthetic agents. The nanofiber surfaces were subsequently functionalized with a supercritical CO2 extract of Inula helenium, thereby introducing a highly bioactive botanical agent not previously explored in this hybrid wound-care context. Comprehensive physical and structural characterizations demonstrated that the bioactive coating serves as a resilient physical barrier, significantly enhancing the dressing’s structural integrity in fluidic environments. In vitro biological evaluations revealed a dual-action mechanism: the biomaterial exhibited excellent biocompatibility and accelerated migration in human dermal fibroblasts (HDFs), achieving nearly 100% in vitro wound closure at 24 h. Conversely, the Inula helenium-coated nanofibers demonstrated distinct, selective cytotoxicity against A375 melanoma cells, effectively restricting their proliferation and reducing their viability. Furthermore, the hybrid platform exhibited significant antioxidant potential and achieved 94% antibacterial inhibition against Staphylococcus aureus. In conclusion, this study presents a sustainable, dual-function wound dressing that suppresses residual cancer cells while promoting healthy tissue regeneration, offering a promising alternative to conventional synthetic oncological dressings.