Akademik Veri Yönetim Sistemi
Current Research in Dental Sciences, cilt.35, sa.4, ss.336-342, 2025 (Scopus, TRDizin)
The investigation of genetic factors influencing peri-implant diseases, particularly peri-implantitis (PI), offers insights into the complex interplay between host genetics and inflammatory responses within oral tissues. Numerous genes encoding cytokines, receptors, and regulatory proteins have been scrutinized for their roles in modulating immune responses and tissue homeostasis around dental implants. Notably, polymorphisms in genes encoding interleukins (IL-1, IL-6, IL-17, IL-10), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinases (MMPs) have emerged as potential genetic markers for susceptibility to peri-implant diseases. Additionally, genes involved in bone metabolism, such as osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANK-L), bone morphogenetic proteins (BMPs), and fibroblast growth factors (FGFs), contribute to peri-implant diseases. Polymorphisms in these genes affect bone resorption and regeneration processes, influencing the stability of dental implants. Variations in these genes can either enhance or hinder bone regeneration, impacting the healing process and the long-term success of implants. Moreover, investigations into less-studied genes like cluster of differentiation 14 (CD14), Chemokine Receptor 2 (CXCR2), and Fragment crystallizable gamma receptor (FcγRs) have revealed additional genetic determinants implicated in the pathogenesis of peri-implant diseases. These genes can influence immune cell function and inflammatory signaling pathways, contributing to the body's response to bacterial biofilms and other factors that compromise implant health. The study of these genetic variations provides a deeper understanding of individual susceptibility to PI and may guide personalized treatment strategies, ultimately improving implant success rate.