The clinical impact of chronopharmacology on current medicine

KAŞKAL M., SEVİM M., Ülker G., Keleş C., Bebitoğlu B.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, cilt.398, sa.6, ss.6179-6191, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 398 Sayı: 6
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s00210-025-03788-7
  • Dergi Adı: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Veterinary Science Database
  • Sayfa Sayıları: ss.6179-6191
  • Anahtar Kelimeler: Chronophysiology, Personalized medicine, Circadian rhythm, Chronopharmacodynamics, Chronopharmacokinetics
  • Marmara Üniversitesi Adresli: Evet

Özet

One of the goals of clinical pharmacology is to optimize patient treatment by adopting new treatment strategies which will increase the efficacy of the treatment and decrease the adverse effects of the drugs. In the literature, it has shown that the effectiveness and toxicity of medications can vary significantly based on when they are administered, making timing a crucial factor in treatment plans. Chronopharmacology a relatively new branch of clinical pharmacology focuses on adjusting drug administration times to enhance patient outcomes. Chronopharmacology is largely influenced by an individual’s circadian rhythm which refers to periodic changes in biological processes depending on the time of the day. The chronopharmacology influences clinical practice, and the accumulating knowledge in this field will likely lead healthcare providers to adopt new strategies for drug treatment regimens. This review aims to summarize the impact of chronopharmacology particularly on current clinical practices and highlight the latest findings related to chronophysiological mechanisms.