Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy

YEŞİL DEVECİOĞLU T., Dayan A., Demirtunc R., Sardas S.

ENDOCRINOLOGIA DIABETES Y NUTRICION, cilt.66, sa.2, ss.90-98, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.endinu.2018.08.010
  • Dergi Adı: ENDOCRINOLOGIA DIABETES Y NUTRICION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.90-98
  • Anahtar Kelimeler: Type 2 diabetes mellitus, Diabetic nephropathy, XRCC3 T241M, rs861539, XRCC1 A399G, rs25487, OXIDATIVE STRESS, ARG399GLN POLYMORPHISM, T241M POLYMORPHISM, BLADDER-CANCER, RISK-FACTOR, ASSOCIATION, POPULATION, METAANALYSIS, DAMAGE, SUSCEPTIBILITY
  • Marmara Üniversitesi Adresli: Evet

Özet

Introduction: Increasing number of experimental and clinical studies suggest a strong relationship between hyperglycemia, oxidative stress, DNA damage and diabetic nephropathy (DN). Also, epidemiologic studies remark an enhanced risk of cancer with type 2 diabetes. This research aims to assess whether the X-ray cross complementing group 3 (XRCC3) gene T241M polymorphism (15861539) and X-ray cross complementing group 1 (XRCC1) gene A399G polymorphism (rs25487) are related with predisposition to type 2 diabetes mellitus (T2DM) and to diabetic nephropathy in Turkish population.