Induction of HGF and VEGF in Hepatic Regeneration after Hepatotoxin-Induced Cirrhosis in Mice

Tekkesin N., Taga Y., Sav A., Almaata I., Ibrisim D.

HEPATO-GASTROENTEROLOGY, cilt.58, sa.107, ss.971-979, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 107
  • Basım Tarihi: 2011
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.971-979
  • Anahtar Kelimeler: Fibrosis, Cirrhosis, Carbon tetrachloride, D-galactosamine, Dimethylnitrosamine, Hepatic regeneration, HEPATOCYTE GROWTH-FACTOR, FACTOR MESSENGER-RNA, RAT-LIVER, CARBON-TETRACHLORIDE, PARTIAL-HEPATECTOMY, EXPRESSION, FIBROSIS, GALACTOSAMINE, RECEPTOR, SYSTEM
  • Marmara Üniversitesi Adresli: Evet

Özet

Background/Aims: Liver cirrhosis is the irreversible end-result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of normal hepatic structure by regenerative nodules and fibrotic tissue. In this study, we elucidated the role of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) in liver regeneration.