Induction of HGF and VEGF in Hepatic Regeneration after Hepatotoxin-Induced Cirrhosis in Mice

Tekkesin N., Taga Y., Sav A., Almaata I., Ibrisim D.

HEPATO-GASTROENTEROLOGY, vol.58, no.107, pp.971-979, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 107
  • Publication Date: 2011
  • Journal Name: HEPATO-GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.971-979
  • Keywords: Fibrosis, Cirrhosis, Carbon tetrachloride, D-galactosamine, Dimethylnitrosamine, Hepatic regeneration, HEPATOCYTE GROWTH-FACTOR, FACTOR MESSENGER-RNA, RAT-LIVER, CARBON-TETRACHLORIDE, PARTIAL-HEPATECTOMY, EXPRESSION, FIBROSIS, GALACTOSAMINE, RECEPTOR, SYSTEM
  • Marmara University Affiliated: Yes

Abstract

Background/Aims: Liver cirrhosis is the irreversible end-result of fibrous scarring and hepatocellular regeneration, characterized by diffuse disorganization of normal hepatic structure by regenerative nodules and fibrotic tissue. In this study, we elucidated the role of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) in liver regeneration.