Influence of oral glycopeptides on the fecal flora of human volunteers: Selection of highly glycopeptide-resistant enterococci

VanderAuwera P., Pensart N., KORTEN V. , Murray B., Leclercq R.

JOURNAL OF INFECTIOUS DISEASES, cilt.173, sa.5, ss.1129-1136, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 173 Konu: 5
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1093/infdis/173.5.1129
  • Sayfa Sayıları: ss.1129-1136


Changes in fecal flora were evaluated in 22 healthy volunteers administered oral vancomycin or teicoplanin in 1989-1991 in Belgium, Evaluation of 5 colonies per subject revealed no glycopeptide-resistant enterococci in the predominant flora before glycopeptide administration; however, large numbers (mostly Enterococcus faecium) emerged by the end of the study in 14 (64%) of the subjects, Pediococci and lactobacilli also increased in number, In 1992, 40 healthy volunteers and 33 cancer patients were evaluated by plating stool samples directly onto selective media containing vancomycin; low numbers of vancomycin-resistant enterococci (<50 cfu/g) were found in 11 (28%) of the 40 and 4 (12%) of the 33 samples, respectively, DNA restriction fragment length polymorphism analysis showed that most isolates were different, but all contained vanA in Tn1546-like elements, These results indicate that vanA and Tn1546-like elements were common in Belgium as early as 1989 and that community-based individuals in that location likely form a major reservoir for glycopeptide-resistant enterococci.