A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia


Ng O. H. , Firtina S., Can I., KARAKAŞ Z., Agaoglu L., Dogru Ö. , ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.32, ss.127-135, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4274/tjh.2013.0296
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Sayfa Sayıları: ss.127-135

Özet

Objective: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event.