Self-healing and cell adhesion properties of dynamic and photo-crosslinking PEG-based dual networks soft hydrogels

Yasar M., OKTAY B., Gurkan A., Apohan N. K.

Journal of Polymer Science, vol.62, no.18, pp.4228-4239, 2024 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 18
  • Publication Date: 2024
  • Doi Number: 10.1002/pol.20240198
  • Journal Name: Journal of Polymer Science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4228-4239
  • Keywords: dynamic covalent bonding, self-healing, soft hydrogels
  • Marmara University Affiliated: Yes

Abstract

Self-healing involves an autonomic response that repairs damage to living systems. In this study, polyethylene glycol (PEG) underwent aldehyde-functionalization using the Albrigh Goldman oxidation technique. Flexible, dynamic crosslink points to encourage self-healing are generated by the formation of acylhydrazone bonds formed between long-chain PEG dialdehyde and adipic acid dihydrazide. Furthermore, methacrylated PEG was synthesized to support the polymer matrix through dynamic covalent bonds. The hydrogels exhibited self-healing within the first 4 hours at room temperature and after 24 h. hydrogels with mechanical performance close to the original were obtained. They have good tensile and elongation strength and are well-suited for interaction with living cells.