In this study, the potential of UV/TiO2 photocatalytic oxidation method to control of membrane fouling caused by natural organic matter (NOM) was investigated under various conditions in submerged MF membrane system. Effect of TiO2 concentration, UV irradiation in the absence of TiO2, TiO2 in the absence of UV irradiation and combination of UV/TiO2 photocatalytic oxidation were investigated. Additionally, intermittent and continuous UV application and initial NOM concentration on the pressure increase and rejections were also studied. The results of synthetic and raw water experiments were compared. It was found that TiO2 concentration is very important parameter by means of permeate pressure increase and removal efficiencies. UV irradiation in the absence of TiO2 or TiO2 in the absence of UV irradiation was not effective and combination of UV/TiO2 photocatalytic oxidation gave better results. Also, intermittent UV application was not as effective as UV/TiO2. The increase in NOM concentration also increased the pressure increase. Synthetic and raw water experiments were compared and raw water experiments gave higher pressure increase and lower removal efficiencies.