On-demand release of fucoidan from 3D-printed cardiac scaffolds based on chitosan/silk fibroin/polyaniline

Moradi A., Nouri S., ULAĞ S., GÜNDÜZ O.

Materials Letters, vol.373, 2024 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 373
  • Publication Date: 2024
  • Doi Number: 10.1016/j.matlet.2024.137178
  • Journal Name: Materials Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: 3D printing, Biomaterials, Chitosan, Fucoidan, PANI, Silk fibroin
  • Marmara University Affiliated: Yes

Abstract

This study explores a promising avenue that contains a chitosan (CS)/polyaniline (PANI)/fucoidan (FUC) composite 3D scaffold for cardiac repair. The scanning electron microscope (SEM) displayed porous, interconnected structures vital for nutrient diffusion and controlled drug release. Tensile testing demonstrated enhanced mechanical strength with increasing PANI and FUC content. The 3D-printed cardiac scaffold with FUC showcased an initial rapid drug release followed by a sustained release, positioning it as a promising vehicle for FUC delivery in cardiac applications. These findings highlight the potential of these composites for cardiac tissue engineering.