Akademik Veri Yönetim Sistemi
13th EFSMA Congress of Sports Medicine, Bucuresti, Romanya, 25 - 27 Eylül 2025, (Yayınlanmadı)
Introduction: Social jetlag (SJL), is misalignment of circadian rhythms and social obligations, disrupts sleep and may affect cognitive performance. This study aims to investigate the individual or combined effects of high-intensity interval training (HIIT), caffeine (CAF), and sex on cognitive and motor function, anxiety- and depressive-like behavior, and the underlying mechanism in a SJL model.
Methods: Sprague Dawley rats (20 males, 20 females) were randomly assigned to five groups: Control, SJL, SJL+CAF, SJL+HIIT, and SJL+CAF+HIIT. SJL was induced via weekly shifts in light-dark cycle. Caffeine (3 mg/kg/day) was administered for 6 weeks, and HIIT was performed 5 days/week using alternating high (80–90%VO₂max) and moderate (50–60%VO₂max) intensity intervals. Behavioral assessments included novel object recognition, Y-maze, open field, hole-board, and elevated plus maze. Brain malondialdehyde (MDA) and glutathione levels, myeloperoxidase (MPO), superoxide dismutase (SOD) and catalase (CAT) activities, and histological analysis were done. Data were analyzed using one-way ANOVA and student’s t test.
Results: In both genders, the prolonged freezing time in the SJL group was reduced in the SJL-CAF and SJL-CAF&HIIT groups, with increased rearing number and distance covered. Depressive behavior was suppressed in females in the SJL-HIIT and SJL-CAF&HIIT groups and in males in SJL-HIIT group (p<0.05-0.001). The difference score was suppressed in males with SJL and increased in SJL-HIIT group (p<0.05). Elevated MDA levels and reduced CAT activity with SJL were reversed in all groups (p<0.05-0.01). SJL induced mild neurodegeneration was improved in SJL-HIIT and SJL-CAF&HIIT groups.
Conclusion: SJL suppressed working memory in males. HIIT improved SJL-induced working and spatial memory and motor alterations and depressive-like behavior, and represented a pronounced neuroprotective effect in both genders. CAF alleviated anxiety-like behavior. Oxidative damage was suppressed via both interventions. This study is the first to suggest HIIT and low-dose caffeine as effective interventions against the adverse effects of SJL.
Key Words: Social jet lag, circadien rhythm, cognitive function, exercise, HIIT, low dose caffeine, sex differences, oxidative stress.