Impact of Helicobacter pylori eradication on the anti-secretory efficacy of lansoprazole in gastroesophageal reflux disease patients


Giral A., Celikel C., Ozdogan O., Tozun N., Ulusoy N., Kalayci C.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.20, ss.1886-1891, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 12
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1440-1746.2005.03896.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Sayfa Sayısı: ss.1886-1891

Özet

Background: Helicobacter pylori eradication was recommended for the prevention of atrophic gastritis in gastroesophageal reflux disease (GERD) patients on long-term omeprazole treatment. It has been also shown that the treatment with proton pump inhibitors produces lower intragastric pH after H. pylori eradication in subjects with peptic ulcer and healthy individuals. The aim of the present study was to test the hypothesis of whether the efficacy of lansoprazole is reduced after the eradication of H. pylori in GERD patients with peptic esophagitis.