Impact of Helicobacter pylori eradication on the anti-secretory efficacy of lansoprazole in gastroesophageal reflux disease patients

Giral A., Celikel Ç., Ozdogan O. C., Tozun N., Ulusoy N., Kalayci C.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.20, no.12, pp.1886-1891, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1440-1746.2005.03896.x
  • Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1886-1891
  • Keywords: gastritis, gastroesophageal reflux disease, Helicobacter pylori, lansoprazole, acid secretion, GASTRIC-ACID-SECRETION, INTRAGASTRIC PH, INFECTION, OMEPRAZOLE, ESOPHAGITIS, BREAKTHROUGH, AUGMENTS, INJURY, CURE
  • Marmara University Affiliated: Yes

Abstract

Background: Helicobacter pylori eradication was recommended for the prevention of atrophic gastritis in gastroesophageal reflux disease (GERD) patients on long-term omeprazole treatment. It has been also shown that the treatment with proton pump inhibitors produces lower intragastric pH after H. pylori eradication in subjects with peptic ulcer and healthy individuals. The aim of the present study was to test the hypothesis of whether the efficacy of lansoprazole is reduced after the eradication of H. pylori in GERD patients with peptic esophagitis.