Monocyte activity in Behcet's disease

Şahin Ş., Lawrence R., DİRESKENELİ R. H., Hamuryudan V., Yazici H., Akoǧlu T.

Revmatologiia, cilt.35, sa.5, ss.424-429, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 5
  • Basım Tarihi: 1996
  • Dergi Adı: Revmatologiia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.424-429
  • Anahtar Kelimeler: monocyte, Behcet's disease, adhesion molecules, NECROSIS-FACTOR-ALPHA, HUMAN ENDOTHELIAL-CELLS, MACROPHAGES, CD14, LIPOPOLYSACCHARIDE, GENERATION, ACTIVATION, ADHERENCE, RECEPTOR, ADHESION
  • Marmara Üniversitesi Adresli: Evet

Özet

Monocytes obtained from patients with Behçet's disease (BD) were examined for differentiation markers (expression of CD14 and antigens reacting with monoclonal antibodies 25F9 and G16/1) and for expression of selected adhesion molecules. There was significantly raised expression of the CD14 molecule, and increased staining with 25F9 and G16/1 antibodies in monocytes obtained from patients with BD. A monocyte activation marker, soluble CD14, was also found to be raised in patients' serum compared with normal serum (8.1 ± 9.2 vs 1.4 ± 0.7 μg/ml). Furthermore, BD patients' monocyte culture supernatants caused significantly increased adhesion of normal neutrophils to endothelial cell monolayers in vitro. All these findings show that BD patients' monocytes are active in vivo and produce a number of pro-inflammatory cytokines which may play a role in the chronic inflammation found in these patients.