The effect of selective internal radiation therapy with yttrium-90 resin microspheres on lung carbon monoxide diffusion capacity

ÖNEŞ T., Eryuksel E., BALTACIOĞLU F., CEYHAN B., ERDİL T. Y.

EJNMMI RESEARCH, cilt.7, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1186/s13550-017-0353-5
  • Dergi Adı: EJNMMI RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Selective internal radiation therapy (SIRT), Lung carbon monoxide diffusion capacity (DLCO), Radiation pneumonitis, NORMAL ORGAN WEIGHTS, II-THE-BRAIN, MAA SCINTIGRAPHY, SHUNT FRACTION, TC-99M MAA, PNEUMONITIS, RADIOEMBOLIZATION, LIVER, CANCER, BRACHYTHERAPY
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Selective internal radiation therapy (SIRT) with embolization of branches of the hepatic artery is a valuable therapeutic tool for patients with hepatic malignancies; however, it is also associated with lung injury risk due to shunting. Diffusion capacity of the lungs for carbon monoxide (DLCO) is a clinically significant lung function test, and worsening in DLCO is suggested to reflect a limited gas exchange reserve caused by the potential toxicity of chemoradiotherapy or it may be a marker of related lung injury. This study aimed to examine the changes in DLCO during SIRT with resin microspheres in newly treated and retreated patients. Forty consecutive patients who received SIRT for a variety of malignant conditions were included. All subjects were treated with Yttrium-90 labelled resin microspheres. DLCO tests were performed after the procedures. In addition, patients were specifically followed for radiation pneumonitis.