Double-Organ Bias in Published Randomized Controlled Trials of Glaucoma

Esen F., Kostek M., Emekli A. S., ERASLAN M.

JOURNAL OF GLAUCOMA, vol.25, no.6, pp.520-522, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1097/ijg.0000000000000369
  • Journal Name: JOURNAL OF GLAUCOMA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.520-522
  • Keywords: randomized controlled trial, glaucoma, statistics, double-organ bias, 2 eyes bias, INTRAOCULAR-PRESSURE, EYES, OPHTHALMOLOGY, UNIT
  • Marmara University Affiliated: Yes

Abstract

Purpose: Most of the statistical tests used in significance testing are based on the assumption that each data entry is independent from other entries, however, we observe that in many articles researchers include data from 2 eyes as independent variables while performing these statistical tests. The aim of this study was to formally survey the prevalence of the above-mentioned "double-organ bias" in randomized controlled trials (RCT) of glaucoma.