Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms


Kolgazi M., Cantali-Ozturk C., Deniz R., ÖZDEMİR KUMRAL Z. N. , YÜKSEL M., ŞİRVANCI S. , ...More

JOURNAL OF SURGICAL RESEARCH, vol.193, no.1, pp.111-118, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 193 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jss.2014.06.057
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.111-118
  • Keywords: Ulcer, Indomethacin, Nesfatin-1, Gastric damage, Antioxidant, TUMOR-NECROSIS-FACTOR, FREE-RADICALS, NITRIC-OXIDE, INDOMETHACIN, INJURY, RAT, INFILTRATION, PATHOGENESIS, INFLAMMATION, GLUTATHIONE

Abstract

Background: Indomethacin is a nonsteroidal anti-inflammatory drug, which is known to produce serious side effects, causing ulcerative lesions. Nesfatin-1, a newly identified anorexigenic peptide, was recently shown to have neuroprotective effects. The aim of the study was to investigate the anti-inflammatory effects of nesfatin-1 on indomethacin-induced gastric ulcer.