Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms

Kolgazi M., Cantali-Ozturk C., Deniz R., ÖZDEMİR KUMRAL Z. N., YÜKSEL M., ŞİRVANCI S., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.193, sa.1, ss.111-118, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 193 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jss.2014.06.057
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.111-118
  • Anahtar Kelimeler: Ulcer, Indomethacin, Nesfatin-1, Gastric damage, Antioxidant, TUMOR-NECROSIS-FACTOR, FREE-RADICALS, NITRIC-OXIDE, INDOMETHACIN, INJURY, RAT, INFILTRATION, PATHOGENESIS, INFLAMMATION, GLUTATHIONE
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Indomethacin is a nonsteroidal anti-inflammatory drug, which is known to produce serious side effects, causing ulcerative lesions. Nesfatin-1, a newly identified anorexigenic peptide, was recently shown to have neuroprotective effects. The aim of the study was to investigate the anti-inflammatory effects of nesfatin-1 on indomethacin-induced gastric ulcer.