Shared Sporadic and Somatic Thyrotropin Receptor Mutations Display More Active In Vitro Activities than Familial Thyrotropin Receptor Mutations

Lueblinghoff J., Eszlinger M., Jaeschke H., Mueller S., BİRCAN R., Gozu H., ...More

THYROID, vol.21, no.3, pp.221-229, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1089/thy.2010.0312
  • Journal Name: THYROID
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.221-229
  • Marmara University Affiliated: Yes

Abstract

Background: Germline thyrotropin receptor (TSHR) mutations are associated with sporadic congenital nonautoimmune hyperthyroidism and familial nonautoimmune hyperthyroidism. Somatic TSHR mutations are associated with toxic thyroid nodules (TTNs). The objective of the study was to define a relation of the clinical appearance and the in vitro activity (IVA) of the TSHR mutations described by several authors for these thyroid disorders.