Shared Sporadic and Somatic Thyrotropin Receptor Mutations Display More Active In Vitro Activities than Familial Thyrotropin Receptor Mutations

Lueblinghoff, Julia; Eszlinger, Markus; Jaeschke, Holger; Mueller, Sandra; BİRCAN, RIFAT; Gozu, HÜLYA; Sancak, Seda; Akalin, Sema; Paschke, Ralf

doi:10.1089/thy.2010.0312

Shared Sporadic and Somatic Thyrotropin Receptor Mutations Display More Active In Vitro Activities than Familial Thyrotropin Receptor Mutations

Atıf İçin Kopyala

Lueblinghoff J., Eszlinger M., Jaeschke H., Mueller S., BİRCAN R., Gozu H., ...Daha Fazla

THYROID, cilt.21, sa.3, ss.221-229, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 3
Basım Tarihi: 2011
Doi Numarası: 10.1089/thy.2010.0312
Dergi Adı: THYROID
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.221-229
Marmara Üniversitesi Adresli: Evet

Özet

Background: Germline thyrotropin receptor (TSHR) mutations are associated with sporadic congenital nonautoimmune hyperthyroidism and familial nonautoimmune hyperthyroidism. Somatic TSHR mutations are associated with toxic thyroid nodules (TTNs). The objective of the study was to define a relation of the clinical appearance and the in vitro activity (IVA) of the TSHR mutations described by several authors for these thyroid disorders.