Molecular Function of Tocopherols in Age Related Diseases


KARADEMİR B. , Ozer N.

CURRENT PHARMACEUTICAL DESIGN, cilt.20, ss.3030-3035, 2014 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 20 Konu: 18
  • Basım Tarihi: 2014
  • Doi Numarası: 10.2174/13816128113196660707
  • Dergi Adı: CURRENT PHARMACEUTICAL DESIGN
  • Sayfa Sayıları: ss.3030-3035

Özet

Tocopherols, with a phytyl side chain in its chroman ring, belong to vitamin E family and have several effects on organisms. They are also classified as therapeutics against different types of human diseases. Especially important roles in cell signaling and gene regulatory mechanisms make tocopherols crucial as therapeutic agents. Aging is accompanied with several degenerative disorders including cardiovascular, neuronal and metabolic diseases. The role of free radical damage in aging has been identified and tocopherols were shown to be involved in age related disorders. Recent studies and future directions will be focused in this review regarding the molecular functions of tocopherols.