Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats

YALMAN K., ŞEN A., ÇEVİK Ö., KADIOĞLU YAMAN S. B., ERTAŞ B., Yıldız S., ...Daha Fazla

JOURNAL OF RESEARCH IN PHARMACY, cilt.26, sa.5, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.29228/jrp.242
  • Dergi Adı: JOURNAL OF RESEARCH IN PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Anahtar Kelimeler: Myrtle, antioxidant activity, anticholinesterase activity, cognitive impairment, AMYLOID-BETA PEPTIDE, OXIDATIVE STRESS, D-GALACTOSE, COGNITIVE IMPAIRMENT, MODEL
  • Marmara Üniversitesi Adresli: Evet

Özet

This study investigated the possible protective and therapeutic effects of Myrtus communis subsp. communis ethanol extract (MC) in aluminum chloride (AlCl3) and D-galactose (D-Gal) induced Alzheimer's disease in rats. MC was orally given to rats as a protective treatment for 90 days and, in other two groups starting from the 60th day MC (100-200 mg/kg) was administered, concomitantly with AlCl3 and D-Gal. Learning and memory functions were evaluated by the behavioral tests. Biological activities of MC treatment were examined in hippocampal tissues by ELISA tests. D-Gal and AlCl3-treated rats showed increased amyloid beta (A ss) and 8-hydroxy-2-deoxyguanosine (8OHdG) levels, acetylcholinesterase activity and decreased neprilysin, Na+-K+ATPase and SOD levels in parallel with a decrease in Novel Object Recognition Test, Morris Water Maze and Passive Avoidance Test scores. On the other hand, MC administration reversed the behavioral impairments and improved learning and memory. Moreover, MC treatment decreased A ss and 8-OHdG levels and acetylcholinesterase activity and increased neprilysin levels, Na+-K+ATPase and SOD levels. Our results suggest that MC has beneficial effects on cognitive and neuronal functions through its anticholinesterase and antioxidant properties.