Akademik Veri Yönetim Sistemi
Radiation Effects and Defects in Solids, 2025 (SCI-Expanded, Scopus)
Sunitinib is a tyrosine kinase inhibitor drug that is used due to its anti-tumor activities. It has various side effects when administered orally. Thus, the development of nanoparticles bearing sunitinib can be advantageous for practical use in anti-tumor treatment. In the present work, sunitinib-encapsulated chitosan nanoparticles were manufactured. Sunitinib-loaded chitosan nanoparticles were also labeled using Technetium-99 m (99mTc). The particle sizes of optimum formulations were found to be below 150 nm, and their zeta potential values were approximately 30 mV. The radiolabeling efficiency and in vitro stability of 99mTc-radiolabeled nanoparticles were also evaluated. Their radiolabeling efficiency was found to be >90% for 6 h. Monte Carlo Simulation is a prediction-based technique that is utilized in drug development, especially to predict the radiation behaviors of radiopharmaceuticals. Its most important advantage in this field is that it is a simulation-based method that can reduce the need for animal experiments and clinical studies. In the current work, the results obtained from the Monte Carlo simulation showed that the radiolabeled sunitinib nanoparticles could effectively interact with tumor tissue. ABBREVIATIONS DLS: dynamic light scattering; NP: nanoparticle; PDI: polydispersity index; PS: particle size; RTLC: radio thin layer chromatography; TKI: tyrosine kinase inhibitor; TPP: tripolyphosphate; ZP: zeta potential.