Antiviral effect of Sanicula europaea L leaves extract on influenza virus-infected cells


TURAN K. , Nagata K., Kuru A.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, cilt.225, ss.22-26, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 225 Konu: 1
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1006/bbrc.1996.1125
  • Dergi Adı: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Sayfa Sayısı: ss.22-26

Özet

We have investigated the influence of Sanicula europaea L. extracts on influenza virus growth in MDCK cells. Fractions I, II: and III separated from Sanicula extract with Sephadex column chromatography were found to be non-toxic against MDCK cells. The growth of influenza A/PR/8/34 was completely inhibited by these fractions, while that of influenza B/Lee/40 was not affected. Fractions II and III have been shown not to have a direct virucidal activity on influenza A/PR/8/34. Influenza A/Vic/1/75 produced microscopic plaques in the presence of the extract. In vitro RNA synthesis with viral RNA-dependent RNA polymerase was also inhibited by a water soluble extract of Sanicula. These observations suggest that the Sanicula extract contains an anti-influenza virus substance. (C) 1996 Academic Press. Inc.