Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2022 – Winter Edition, Bucuresti, Romanya, 24 - 26 Kasım 2022, ss.55
The incidence of cardiovascular diseases has increased dramatically in the past decay, making it the deadliest disease nationwide. The emergence of engineered cardiac tissues has broadened the spectrum of potential therapies based on biopolymer scaffolds; therefore, the ability to control and localize 3D-printed cardiac patches has provided a desirable and feasible approach for drug delivery. This study has focused on printing a novel 3D scaffold with different biopolymers, including Chitosan, Silk Fibroin, and PANI. In addition, Fucoidan, which has shown a promising therapeutic impact on all phases of cardiovascular diseases, such as an anti-inflammatory response, has been loaded into the hydrogel to boost the scaffolds' efficacy. Moreover, the biocompatibility, chemical, thermal, morphological, mechanical, swelling and degradation properties were applied to investigate the scaffold's characterization. The fabrication of chitosan 5%, silk fibroin 1%, and PANI 1 mg/3 mg with Fucoidan 10 mg demonstrated a favorable possibility for a functional 3D-printed cardiac patch.