Colistin nephrotoxicity in critically ill patients after implementation of a new dosing strategy


Ozel A. S. , Ergonul O., KORTEN V.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, cilt.13, sa.10, ss.877-885, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Konu: 10
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3855/jidc.11413
  • Dergi Adı: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
  • Sayfa Sayıları: ss.877-885

Özet

Introduction: Intravenous colistin is increasingly used to treat multidrug-resistant Gram-negative infections. Highly variable nephrotoxicity rates have been reported. Recent PK/PD studies propose a loading dose and a maintenance dose for better efficacy, but data on the renal toxicity of such regimens are rare. This study aimed to evaluate the incidence and risk factors for nephrotoxicity related to colistin after implementation of a new dosing regimen including a loading dose.