In vitro microsomal metabolism of nuclear chloro substituted secondary amines and imines


KÜÇÜKGÜZEL İ. , ÜLGEN M., GORROD J. W.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, vol.22, no.4, pp.351-358, 1997 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 4
  • Publication Date: 1997
  • Title of Journal : EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • Page Numbers: pp.351-358

Abstract

The metabolism of N-(4-chlorobenzyl)-4-chloroaniline (CBCA), N-(4-chlorobenzyl)-4-chlorobenzylamine (CBCBA), and N-(4-chlorobenzylidene)-4-chlorobenzylamine (CBDCBA) were studied in vitro using rat liver microsomal preparations. The secondary amines produced the corresponding N-oxidation Products (hydroxylamines and nitrones) and dealkylation products (4-chlorobenzaldehyde and primary amines). Both secondary amines failed to produce the corresponding amides, whilst the parent imine was detected as a metabonate. CBDCBA, the intermediate imine of CBCBA metabolism, was also incubated under similar conditions. However, no oxaziridine was detected.