5-hydroxytryptamine release in the anterior hypothalamic and the hippocampal areas of cholestatic rats

Terzioglu B., Aypak C., Yananli H. R., Kucukibrahimoglu E., Yurdaydin M., Goren M.

LIFE SCIENCES, cilt.78, sa.10, ss.1078-1083, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 10
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.lfs.2005.06.025
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1078-1083
  • Anahtar Kelimeler: bile duct resected rats, cholestasis, 5-HT, anterior hypothalamus, hippocampus, PITUITARY-ADRENAL AXIS, BETA-ENDORPHIN, LIVER-DISEASE, SEROTONIN, FATIGUE, EXERCISE, MODEL, RESPONSIVENESS, NEUROENDOCRINE, MICRODIALYSIS
  • Marmara Üniversitesi Adresli: Evet

Özet

Cholestasis contributes to the genesis of fatigue through several mechanisms. Among these mechanisms, affected serotonergic neurotransmission is important in the pathogenesis of central fatigue. Previously, elevated levels of 5-hydroxyindole acetic acid (5-HIAA), the metabolite of 5-hydroxytryptamine (5-HT) and increased 5-HT(2) receptor density were demonstrated in the anterior hypothalamus and in the hippocampus of bile duct resected rats (BDR), respectively. The aim of this paper is to demonstrate evoked 5-HT release in selected brain regions like anterior hypothalamus and hippocampal CA1 regions of cholestatic rats using BDR rats as an experimental model for cholestasis.