5-hydroxytryptamine release in the anterior hypothalamic and the hippocampal areas of cholestatic rats
LIFE SCIENCES, cilt.78, sa.10, ss.1078-1083, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 10
- Basım Tarihi: 2006
- Doi Numarası: 10.1016/j.lfs.2005.06.025
- Dergi Adı: LIFE SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1078-1083
- Anahtar Kelimeler: bile duct resected rats, cholestasis, 5-HT, anterior hypothalamus, hippocampus, PITUITARY-ADRENAL AXIS, BETA-ENDORPHIN, LIVER-DISEASE, SEROTONIN, FATIGUE, EXERCISE, MODEL, RESPONSIVENESS, NEUROENDOCRINE, MICRODIALYSIS
- Marmara Üniversitesi Adresli: Evet
Özet
Cholestasis contributes to the genesis of fatigue through several mechanisms. Among these mechanisms, affected serotonergic neurotransmission is important in the pathogenesis of central fatigue. Previously, elevated levels of 5-hydroxyindole acetic acid (5-HIAA), the metabolite of 5-hydroxytryptamine (5-HT) and increased 5-HT(2) receptor density were demonstrated in the anterior hypothalamus and in the hippocampus of bile duct resected rats (BDR), respectively. The aim of this paper is to demonstrate evoked 5-HT release in selected brain regions like anterior hypothalamus and hippocampal CA1 regions of cholestatic rats using BDR rats as an experimental model for cholestasis.