Glial fibrillary acidic protein (GFAP)-antibody in children with focal seizures of undetermined cause

Savas M., Tzartos J., Kucukali C. I., Dursun E., Karagiorgou K., Gezen Ak D., ...Daha Fazla

ACTA NEUROLOGICA BELGICA, cilt.121, sa.5, ss.1275-1280, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 121 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s13760-020-01361-y
  • Dergi Adı: ACTA NEUROLOGICA BELGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1275-1280
  • Anahtar Kelimeler: Glial fibrillary acidic protein, Epilepsy, Seizure, Antibody, Autoimmunity, NEURONAL AUTOANTIBODIES, AUTOIMMUNE, EPILEPSY, ASTROCYTOPATHY, ENCEPHALITIS, ORGANIZATION
  • Marmara Üniversitesi Adresli: Evet

Özet

Anti-neuronal antibodies that are related with autoimmune encephalitis syndromes may also be found in children with new onset seizures or chronic epilepsy. To unravel the significance of autoimmune astrocytopathy in epilepsy, we investigated serum antibody to glial fibrillary acidic protein (GFAP), another autoantigen described in autoimmune encephalitis with seizures, in 38 children with focal seizures of undetermined cause. GFAP antibody was screened with cell based assay and indirect immunohistochemistry and was found in two boys with normal brain MRI and unrevealing medical history prior to seizures. The 2-year-old boy had chronic treatment-resistant frontal lobe epilepsy. The 2.5-year-old boy had a single episode of focal seizures and remained seizure free thereafter in a follow-up period of 4 years. Nevertheless, he showed severe cognitive and language impairment. These results suggest that autoimmune astrocytopathy may be present in some epilepsy patients. Whether this immune response is a bystander effect generated by seizure-induced astrocytosis or directly involved in epileptogenesis needs to be further studied.