Akademik Veri Yönetim Sistemi
EuroPerio11, Viyana, Avusturya, 14 - 17 Mayıs 2025, sa.28, (Özet Bildiri)
Background & Aim: This study aimed to investigate effect oforally administration of two doses of Aronia melanocarpa (AM)extract on palatal mucosa secondary wound healing in rats.Methods: A total of 35 male systemically healthy Wistar al-bino rats were used in this study. In all rats, diameter of 4 mmmucoperiosteal defect was created in center of palatal mucosa.Then rats were randomly divided into saline (5 mL/kg saline),AM5 (5 mL/kg AM), AM10 (10 mL/kg AM) groups. The ratswere sacrificed 0, 7 and 21 days after defects were created, andserum samples were collected. Photographs of the wound area(WA) were taken for measuring WA using Image-J computerprogram. After routine histological tissue follow-up, on sections,hematoxylin-eosin staining was performed for histomorpho-metric measurement of the distance between epithelial margins(EM) and evaluation of vascularization and inflammatory cellinfiltration. Picro Sirius Red staining was applied to evaluatecollagen density. Total antioxidant status (TAS) and total oxi-dant satus (TOS) in serum samples were determined by ELISA.Results: On Day 7, AM groups were found to have a smaller WAand EM than saline group (p < 0.05). Inflammatory cell infiltra-tion was higher in saline group than AM groups on 7 and 21 days(p < 0.05). Collagen density of AM groups was higher than salinegroup on 7 and 21 days (p < 0.05). The vascularization of salinegroup was higher than AM groups at Day 7 (p > 0.05), whereasAM groups were higher than saline group at Day 21 (p < 0.05).TAS of AM groups were higher than saline group at Days 7 and21 (p < 0.05). TOS of AM groups was higher than saline group atDay 21 (p < 0.05).Conclusions: This study findings suggest that AM extract ad-ministration orally impact on palatal mucosa secondary woundhealing with reducing inflammation by affecting TAS and TOSin rats.