Akademik Veri Yönetim Sistemi
Journal of the Turkish Chemical Society, Section A: Chemistry, cilt.8, sa.1, ss.329-342, 2021 (Scopus)
In this study, the anti-cholinesterase activities of different extracts of Achillea lycaonica, A.vermicularis and A. nobilis L. subsp. neilreichii (Kerner) Formanek species were examined and then traceelements (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, and Pb) of the plants were analyzed by ICP-MS. Thepharmacokinetic properties of the phenolic compounds of these plants previously analyzed by us and theADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) profiles of the trace elements weidentified in this study were estimated. According to the data obtained, it was determined that all threeplants showed high acetyl-cholinesterase inhibitory activity. The concentration of trace elements was lowerthan that declared by WHO, except for the A. lycaonica. It was determined that V, Cr, Fe, Co, and As metalsin A. lycaonica exceeded the limit values determined by WHO. According to ADMET estimates, it is thoughtthat the toxic values of all three plants are not high, and therefore the use of A. nobilis and A. vermicularisplants does not pose any health risk but A lycaonica should be used carefully due to the presence of heavymetals.