Synthesis and preliminary anticancer activity of new 1H-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones. Part II

Dogan H., Duran A., Rollas S.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol.44, no.11, pp.2301-2307, 2005 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 11
  • Publication Date: 2005
  • Journal Name: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2301-2307
  • Keywords: 1H-4,5-dihydro-3-(3-hydroxyl-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones, anticancer activity, PRIMARY CYTOTOXICITY EVALUATION, ANTITUMOR AGENTS, DERIVATIVES, SCREEN
  • Marmara University Affiliated: No

Abstract

The compounds 1H-4,5-dihydro-3-(3-hydroxy-2-napthyl)-4-substituted-1,2,4-triazoline-5-thiones have been synthesised From 3-hydroxy-2-naphthoic acid hydrazide in two steps, The structural clucidation of the synthesised compounds has been performed by H-1 NMR and mass spectroscopic data besides elemental analyses. Some of the compounds are tested in vitro for their ability to inhibit growth of 60 different human cancer cell lines by the National Cancer Institute and notable cytotoxic effect oil some cancer cell lines is observed from some of them as expected in comparison with the control agent 5-fluorouracil.