Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women

Kaya Z., AKKİPRİK M., Karabulut S., Peker İ., GÜLLÜ AMURAN G., Ozmen T., ...Daha Fazla

JOURNAL OF CLINICAL LABORATORY ANALYSIS, cilt.31, sa.5, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/jcla.22083
  • Dergi Adı: JOURNAL OF CLINICAL LABORATORY ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: breast cancer, insulin-like growth factor-binding protein 7, methylation, telomere, telomere length, TIME QUANTITATIVE PCR, MALIGNANT-TRANSFORMATION, CELLULAR SENESCENCE, COLORECTAL-CANCER, GENE-EXPRESSION, DOWN-REGULATION, CELLS, IGFBP7, ASSOCIATION, CARCINOMA
  • Marmara Üniversitesi Adresli: Evet

Özet

BackgroundBoth insulin-like growth factor-binding protein 7 (IGFBP7) and telomere length (TL) are associated with proliferation and senescence of human breast cancer. This study assessed the clinical significance of both TL and IGFBP7 methylation status in breast cancer tissues compared with adjacent normal tissues. We also investigated whether IGFBP7 methylation status could be affecting TL.