Cefaclor, a cephalosporin antibiotic, delays gastric emptying rate by a CCK-A receptor-mediated mechanism in the rat

Bozkurt A., Deniz M., Yegen B.

BRITISH JOURNAL OF PHARMACOLOGY, cilt.131, sa.3, ss.399-404, 2000 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 131 Sayı: 3
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1038/sj.bjp.0703585
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.399-404
  • Anahtar Kelimeler: cephalosporins, gastric emptying, cholecystokinin (CCK), CCK-A receptors, capsaicin, STIMULATE CHOLECYSTOKININ SECRETION, PANCREATIC ENZYME SECRETION, TRYPSIN-INHIBITOR, DIABETIC GASTROPARESIS, FEEDBACK-REGULATION, SENSORY NEURONS, MONITOR PEPTIDE, BINDING-SITES, STC-1 CELLS, ERYTHROMYCIN
  • Marmara Üniversitesi Adresli: Evet

Özet

1 Studies in vitro suggest that cephalosporin antibiotics release the gut hormone cholecystokinin. Cholecystokinin is known to inhibit gastric emptying. Here we examine the effects of cefaclor on gastric emptying and intestinal motility.