Intrinsic factor and vitamin B12 complex-loaded poly[lactic-co-(glycolic acid)] microspheres: preparation, characterization and drug release
POLYMER INTERNATIONAL, cilt.57, sa.2, ss.372-377, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 2
- Basım Tarihi: 2008
- Doi Numarası: 10.1002/pi.2371
- Dergi Adı: POLYMER INTERNATIONAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.372-377
- Marmara Üniversitesi Adresli: Evet
Özet
BACKGROUND: Vitamin B12 is an essential vitamin required by all mammals. Absorption of vitamin B12 is facilitated by binding of intrinsic factor-vitamin B12 complex to specific receptors in the ileum. In humans a deficiency of this vitamin or a lack of intrinsic factor leads to pernicious anaemia. The major objective of the present study was to prepare intrinsic factor-vitamin B12 complex-loaded poly[lactic-co-(glycolic acid)] (PLGA)-based microparticles and to investigate their release kinetics.