Intrinsic factor and vitamin B12 complex-loaded poly[lactic-co-(glycolic acid)] microspheres: preparation, characterization and drug release

DEMİR S., OGAN A., KAYAMAN APOHAN N.

POLYMER INTERNATIONAL, cilt.57, sa.2, ss.372-377, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1002/pi.2371
  • Dergi Adı: POLYMER INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.372-377
  • Marmara Üniversitesi Adresli: Evet

Özet

BACKGROUND: Vitamin B12 is an essential vitamin required by all mammals. Absorption of vitamin B12 is facilitated by binding of intrinsic factor-vitamin B12 complex to specific receptors in the ileum. In humans a deficiency of this vitamin or a lack of intrinsic factor leads to pernicious anaemia. The major objective of the present study was to prepare intrinsic factor-vitamin B12 complex-loaded poly[lactic-co-(glycolic acid)] (PLGA)-based microparticles and to investigate their release kinetics.