Radiation field size and dose determine oncologic outcome in esophageal cancer

Gemici C., Yaprak G., BATIREL H. F., Ilhan M., Mayadagli A.

WORLD JOURNAL OF SURGICAL ONCOLOGY, vol.14, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2016
  • Doi Number: 10.1186/s12957-016-1024-0
  • Journal Name: WORLD JOURNAL OF SURGICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Esophageal cancer, Concomitant chemoradiotherapy, Locoregional recurrence, Overall survival, SQUAMOUS-CELL CARCINOMA, POSITRON-EMISSION-TOMOGRAPHY, PHASE-II, PREOPERATIVE CHEMORADIOTHERAPY, NEOADJUVANT CHEMORADIOTHERAPY, CONCURRENT CHEMOTHERAPY, TRANSHIATAL RESECTION, CLINICAL-IMPLICATIONS, RECURRENCE PATTERN, RANDOMIZED-TRIAL
  • Marmara University Affiliated: Yes

Abstract

Background: Locoregional recurrence is a major problem in esophageal cancer patients treated with definitive concomitant chemoradiotherapy. Approximately half of the patients fail locoregionally. We analyzed the impact of enlarged radiation field size and higher radiation dose incorporated to chemoradiotherapy on oncologic outcome.