Improvement of antibacterial and biocompatibility properties of electrospray biopolymer films by ZnO and MCM-41

Mutlu E. C. , YILDIRIM A., Yildirm M., Ficai A., Ficai D., OKTAR F. N. , ...Daha Fazla

POLYMER BULLETIN, cilt.77, sa.7, ss.3657-3675, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Konu: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00289-019-02937-2
  • Sayfa Sayıları: ss.3657-3675


This study aims the improvement of antibacterial and biocompatibility properties of electrospray ternary blends of chitosan/poly(ethylene glycol)/hyaluronic acid. It conserves microscale particle structure even after incorporating zinc oxide (ZnO), the zeolite Mobil Composition of Matter No. 41 (MCM41) and penicillin G during this technique. Three different electrospray (ESP) blend compositions (ESPI, ESPII and ESPIII) have been produced in order to improve both antibacterial activity against to bothgram-positive and gram-negativebacteria and biocompatibility. Results of FTIR spectroscopy and microscopy verified with SEM, EDS and AFM analyses. Hyaluronic acid surface has been specified definitely through ZnO-based ESPI surface composed of heterogeneously dispersed microparticles. Surface structures of ESPII and ESPIII have more homogenously dispersed microparticles as hill-valley surface by the aid of MCM 41-PEN. Antibacterial activity has been performed by Kirby-Bauer method. ESPI has good antibacterial activity against both gram-positive (S. aureusandS. epidermidis) and gram-negative bacteria (E. cloacea). Each electrospray film displayed good biocompatibility against to mouse fibroblast cell line L929 (ATTC number CCL-1). The highest amount of cell proliferation has been detected on ESPIII surface.