Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide

Kocyigit-Kaymakcioglu B., Oruc-Emre E. E., Unsalan S., Rollas S.

MEDICINAL CHEMISTRY RESEARCH, cilt.18, sa.4, ss.277-286, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00044-008-9126-z
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.277-286
  • Anahtar Kelimeler: Hydrazide-hydrazones, Antituberculosis activity, 4-fluorobenzoic acid hydrazide, ANTIMYCOBACTERIAL ACTIVITY, ANTIMICROBIAL ACTIVITY, TUBERCULOSIS, DERIVATIVES
  • Marmara Üniversitesi Adresli: Evet

Özet

A series of substitututed methylene/ethylene 4-fluorophenylhydrazide derivatives (3a-p) was synthesized with the aim of evaluating their antimycobacterial activity toward a strain of Mycobacterium tuberculosis H37Rv. Their chemical structures were confirmed by H-1-nuclear magnetic resonance (NMR) and electrospray mass spectrometry (ES-MS) spectral data, and elemental analysis. The in vitro antimycobacterial evaluation was performed according to the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) antituberculosis drug discovery program. Compound 3a, 4-fluorobenzoic acid [(2,6-dichlorophenyl) methylene]hydrazide, showed the highest inhibitory activity of all the compounds under study.